Christopher P Chen Selected Research

Alzheimer Disease (Alzheimer's Disease)

1/2024	Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort.
1/2024	Serum Placental Growth Factor as a Marker of Cerebrovascular Disease Burden in Alzheimer's Disease.
12/2023	Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer's disease and vascular dementia.
11/2023	Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ42 , phosphorylated α-synuclein, and synaptopathology.
5/2023	Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer's disease but not Lewy body dementias.
1/2023	Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline.
1/2023	Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients with concomitant cerebral small vessel disease.
11/2021	Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances.
10/2021	Plasma P-tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant cerebrovascular disease.
1/2021	Plasma osteopontin as a biomarker of Alzheimer's disease and vascular cognitive impairment.

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Christopher P Chen Research Topics

Disease

27	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 08/2006
27	Dementia (Dementias) 01/2024 - 04/2011
12	Cognitive Dysfunction 01/2023 - 04/2011
11	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2024 - 08/2016
8	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2024 - 06/2011
6	Stroke (Strokes) 04/2024 - 03/2010
4	Ischemic Stroke 04/2024 - 03/2010
4	Cerebral Small Vessel Diseases 04/2024 - 01/2023
4	Inflammation (Inflammations) 01/2024 - 01/2020
4	Parkinson Disease (Parkinson's Disease) 05/2023 - 01/2016
3	Atrophy 01/2023 - 10/2021
3	Vascular Diseases (Vascular Disease) 12/2021 - 01/2020
3	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2020 - 12/2010
2	Hypertension (High Blood Pressure) 04/2024 - 01/2023
2	Amyloid Plaque 05/2023 - 01/2017
2	Lewy Body Disease (Lewy Body Dementia) 01/2019 - 01/2014
2	Mixed Dementias 10/2016 - 04/2012
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 04/2024
1	Atrial Fibrillation 04/2024
1	Transient Ischemic Attack 04/2024
1	Infarction (Infarctions) 01/2024
1	Coronary Disease (Coronary Heart Disease) 01/2023
1	Carotid Stenosis (Carotid Artery Stenosis) 01/2023
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2023
1	Astrocytoma (Pilocytic Astrocytoma) 01/2020
1	Neuroinflammatory Diseases 01/2020
1	Neurologic Manifestations (Neurological Manifestations) 01/2019
1	Heart Diseases (Heart Disease) 01/2019
1	Atherosclerosis 01/2019
1	Infections 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 08/2016
1	Ischemia 10/2014
1	Lacunar Stroke 01/2014

Drug/Important Bio-Agent (IBA)

15	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2014
12	Amyloid (Amyloid Fibrils)IBA 04/2024 - 01/2014
7	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2014
4	SynucleinsIBA 11/2023 - 01/2016
4	ProteomeIBA 01/2023 - 11/2014
4	Cholinergic Agents (Cholinergics)IBA 10/2016 - 01/2010
3	CytokinesIBA 05/2023 - 01/2020
3	Amyloid beta-PeptidesIBA 01/2023 - 10/2021
3	Retinaldehyde (Retinal)IBA 01/2019 - 08/2013
2	SphingolipidsIBA 12/2023 - 10/2014
2	IntegrinsIBA 12/2023 - 01/2023
2	Phospholipids (Phosphatides)FDA LinkGeneric 11/2023 - 10/2014
2	LipidsIBA 11/2023 - 01/2020
2	Cathepsin DIBA 01/2023 - 01/2019
2	ErgothioneineIBA 08/2022 - 12/2021
2	AMPA Receptors (AMPA Receptor)IBA 01/2014 - 06/2011
2	Serotonin (5 Hydroxytryptamine)IBA 01/2010 - 05/2008
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2010 - 08/2006
1	AnticoagulantsIBA 04/2024
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2024
1	Glial Fibrillary Acidic ProteinIBA 04/2024
1	BrevicanIBA 01/2024
1	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 01/2024
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2024
1	Interleukin-10 (Interleukin 10)IBA 05/2023
1	Interleukin-13IBA 05/2023
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 05/2023
1	SaltsIBA 01/2023
1	Pemetrexed (MTA)FDA Link 01/2023
1	Peptide Hydrolases (Proteases)FDA Link 01/2023
1	Extracellular Matrix ProteinsIBA 01/2023
1	GelatinasesIBA 01/2023
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2023
1	Matrix Metalloproteinases (MMPs)IBA 01/2023
1	Cyclophilin AIBA 01/2023
1	Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA 01/2023
1	AntioxidantsIBA 12/2021
1	hercynineIBA 12/2021
1	ThionesIBA 12/2021
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021
1	OsteopontinIBA 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	3- (3,5- dichlorophenyl)- 1- methyl- 2,5- pyrrolidinedione (DPMS)IBA 01/2019
1	5- aminocarbonyl- 10,11- dihydro- 5H- dibenzo(a,d)cyclohepten- 5,10- imine (ADCI)IBA 01/2019
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Interleukin-8 (Interleukin 8)IBA 01/2017
1	Muscarinic M1 ReceptorIBA 10/2016
1	GTP-Binding Proteins (G-Protein)IBA 10/2016
1	Growth Differentiation Factor 15IBA 08/2016
1	RelaxinIBA 02/2016
1	collapsin response mediator protein-2IBA 01/2016
1	Adenosine Triphosphatases (ATPase)IBA 11/2014
1	AcidsIBA 01/2014
1	danaparoid (Orgaran)FDA Link 08/2013
1	Histamine H3 Receptors (Histamine H3 Receptor)IBA 04/2012
1	Histamine (Histamine Dihydrochloride)FDA Link 04/2012
1	AMPA 2 glutamate receptor ionotropicIBA 06/2011
1	Peptides (Polypeptides)IBA 06/2011
1	Donepezil (Aricept)FDA LinkGeneric 03/2011
1	Galantamine (Galanthamine)FDA LinkGeneric 03/2011

Therapy/Procedure

3	Therapeutics 04/2024 - 04/2012
1	Secondary Prevention 04/2024
1	Immunomodulation 01/2020
1	Institutionalization (Institutionalized Persons) 04/2011